In Case You Missed It! February 2024

This newsletter highlights a selection of recently published peer-reviewed articles that piqued our interest, grouped by their most relative modality.

We hope you find these recent findings useful and of value in your day-to-day practice.

Home Hemodialysis Recent Findings

Vancomycin and daptomycin dosing recommendations in patients receiving home hemodialysis using Monte Carlo simulation

Therapeutic vancomycin and daptomycin levels were analyzed in 5,000 simulated home hemodialysis (HHD) patients.  Initial vancomycin and daptomycin doses were defined for 10 common HHD treatment regimens based on HHD treatment duration, days per week, and dialysate volume.

Peritoneal Dialysis Recent Findings

Predicting transfer to hemodialysis using the peritoneal dialysis surprise question

95 Peritoneal Dialysis (PD) nurses and 80 treating nephrologists were separately asked the PD ‘surprise question’: ‘Would you be surprised if this patient transferred to HD in the next six months?’ Patients were categorized into transfer risk levels (low-risk/high-risk) based on their nurse’s and/or nephrologist’s assessment (yes/no) and followed for 6-months to determine if the palliative care ‘surprise question’ could be modified and adapted as a PD transition risk stratification tool.

Hemodialysis Versus Peritoneal Dialysis Drug Expenditures: A Comparison Within the Private Insurance Market

Investigators analyzed Blue Cross Blue Shield average annual insurance expenditures for PD, and propensity-score-matched in-center hemodialysis patients. Expenditures for both cohorts were aggregated by payment type: injectable ESKD; oral phosphate binders; inpatient hospitalization (including hospitalizations, observation stays, emergency room visits, and acute and subacute rehabilitation stays); nondrug facility; other (i.e., non-dialysis outpatient and physician fee); total dialysis and aggregate payments.

More rapid progression of brain atrophy in patients on peritoneal dialysis compared with hemodialysis: The VCOHP Study

This study compared the annual change in ratios of total gray matter volume in 42 PD and 25 HD patients who underwent initial brain magnetic resonance imaging (MRI) and a second MRI after two years.

In-Center Hemodialysis Recent Findings

Effect of Dialysate and Plasma Sodium on Mortality in a Global Historical Hemodialysis Cohort

Mortality risk, stratified by dialysate sodium level, was analyzed in 68,196 Fresenius Medical Care patients. 63.2% of patients received a dialysate sodium of 138 mmol/L, 15.8% of patients received a dialysate sodium of 139 mmol/L, 20.7% of patients received a dialysate sodium of 140 mmol/L, and 0.4% of patients received other dialysate sodium prescriptions between 132 to 137 mmol/L; only 2% of patients had prescription changes during follow-up.

End-Stage Kidney Disease Progression Recent Findings

Characteristics and Outcomes of Patients with Pregnancy-Related End-Stage Kidney Disease

A total of 341 patients with pregnancy-related End Stage Kidney Disease (ESKD), were compared to the general US birthing population. The investigators review significant differences in demographics, clinical characteristics, pre-ESKD care, survival, and access to kidney transplantation between the two cohorts.

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